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Regenxbio announced positive interim results from an early-to-mid stage trial of its experimental gene therapy for Duchenne muscular dystrophy. The data showed continued improvement in muscle function along with a clean safety profile. This represents potential progress in treating this severe genetic muscle-wasting disease.

• The trial is in early-to-mid stage phase, indicating the therapy is still in development and requires further testing
• Patients demonstrated continued improvement in muscle function, a key therapeutic goal for Duchenne muscular dystrophy
• The therapy showed a 'clean safety profile' with no significant adverse events reported in the interim analysis

The U.S. Energy Information Administration reported that crude oil inventories increased by 3.8 million barrels to 443.1 million barrels in the week ending March 6, significantly exceeding analysts' expectations of a 1.1 million-barrel rise. Meanwhile, gasoline stocks fell by 3.7 million barrels and distillate inventories dropped by 1.3 million barrels, both exceeding forecast declines.

• Crude stocks rose 3.8 million barrels versus expectations of 1.1 million, with refinery utilization increasing 1.6 percentage points to 90.8%
• Gasoline inventories fell 3.7 million barrels to 249.5 million (forecast: 2.6 million drop), while distillate stocks declined 1.3 million barrels (forecast: 0.7 million drop)
• Net U.S. crude imports increased by 661,000 barrels per day, and refinery crude runs rose by 328,000 barrels per day during the week

A federal judge has ruled that billionaire Leon Black, co-founder of Apollo Global Management, may be deposed in a civil lawsuit against Bank of America. The lawsuit was brought by women who accuse the bank of facilitating their sexual abuse by Jeffrey Epstein. U.S. District Judge Jed Rakoff scheduled a hearing regarding Black's upcoming deposition.

• The lawsuit alleges Bank of America facilitated sexual abuse by Jeffrey Epstein, with victims now seeking to depose Leon Black as part of the case
• Manhattan-based U.S. District Judge Jed Rakoff set a hearing for 3 p.m. EDT to discuss the deposition details
• Leon Black is a billionaire and co-founder of Apollo Global Management, though the court filing did not specify his connection to the allegations

The National Transportation Safety Board will hold a hearing on March 31 to determine the probable cause of two fatal crashes involving Ford Motor's BlueCruise advanced driver assistance system. Both the NTSB and National Highway Traffic Safety Administration have been investigating BlueCruise since 2025 to review system limitations and evaluate drivers' response capabilities in certain scenarios.

• BlueCruise is a hands-free driving system that operates on 97% of U.S. and Canadian highways without intersections or traffic signals
• Federal investigations are focused on assessing system limitations and drivers' ability to respond to certain driving scenarios
• NTSB Chair Jennifer Homendy confirmed the board will meet later in March to review the fatal crashes

BMW is recalling 147,830 vehicles in China due to a manufacturing defect in the starter motor that could cause starting difficulties and, in extreme cases, pose a fire risk. The recall affects multiple imported BMW models manufactured between July 2020 and December 2022. This China recall is part of a broader global recall announced by the German automaker in February.

• The recall covers imported BMW 2 Series, 4 Series, 5 Series, 6 Series, 7 Series, X4, X5, X6, and Z4 vehicles manufactured between July 31, 2020 and December 22, 2022
• The defect involves a manufacturing issue with the starter motor that could result in difficulty starting the vehicle or present a fire risk in extreme cases
• The China recall is part of a global recall initiative announced by BMW in February after the potential starter motor defect was discovered

Tesla's China-made electric vehicle sales surged 91% year-over-year in February 2025, reaching 58,600 units for its Model 3 and Model Y vehicles produced at its Shanghai plant. The strong performance marks the fourth consecutive month of sales growth, though results benefited from a low comparison base last year and were impacted by seasonal factors including Lunar New Year production adjustments.

• Sales of 58,600 units represented a 91% increase from February 2024, following a 9.3% rise in January, but were down 15.2% month-over-month from January 2025
• February deliveries were affected by a partial assembly line shutdown for the refreshed Model Y during the Lunar New Year holiday period
• The Shanghai plant's production figures include both domestic sales and exports to markets including Europe

Eli Lilly announced a $3 billion investment in China over the next decade to expand its supply chain and build production capacity for orforglipron, its type-2 diabetes and obesity treatment. The pharmaceutical giant has already submitted a marketing application for the drug to China's regulator and plans to establish localized manufacturing for oral solid dosage forms.

• The $3 billion investment will focus on expanding supply chain capacity and building production facilities specifically for orforglipron, an oral diabetes and obesity treatment
• Eli Lilly submitted a marketing application for orforglipron to China's drug regulator at the end of 2025
• The company plans to establish a localized manufacturing and supply system for oral solid dosage forms in China

Toyota Motor is recalling 550,007 vehicles in the United States due to a faulty seat back mechanism that may fail to lock properly, increasing injury risk. The recall was announced by the U.S. National Highway Traffic Safety Administration (NHTSA) on Wednesday, March 11.

• The recall affects over half a million Toyota vehicles across the U.S. market
• The defect involves a seat back locking mechanism that could malfunction, potentially allowing seats to move unexpectedly and increase passenger injury risk during normal driving or crashes
• NHTSA made the official announcement, indicating federal safety regulators identified the issue as significant enough to require manufacturer action

Inditex, the world's largest fast fashion company and owner of Zara, reported 9% currency-adjusted sales growth for the early first quarter (February 1 to March 9), meeting analyst expectations. The company also announced 7% currency-adjusted sales growth for the full year 2025.

• Early Q1 sales growth of 9% (currency-adjusted) from February 1 to March 9 met market expectations
• Full year 2025 sales increased 7% on a currency-adjusted basis
• Results demonstrate continued momentum for the world's biggest fast fashion retailer

Cathay Pacific Airways reported a 9.5% increase in full-year net profit to HK$10.83 billion ($1.38 billion) for the year ended December 31, driven by strong passenger growth, increased capacity, and steady cargo performance. The Hong Kong flagship carrier's results exceeded analyst estimates of HK$10.05 billion.

• Net profit reached HK$10.83 billion ($1.38 billion), surpassing LSEG SmartEstimate of HK$10.05 billion
• Performance was driven by robust passenger growth, increased capacity expansion, and consistent cargo operations
• Results topped the previous year's profit of HK$9.89 billion recorded in 2024

SoftBank's PayPay is expected to price its IPO at the low end of its marketing range due to Middle East tensions affecting markets, according to sources. The Japanese payment app operator's offering is oversubscribed by more than five times, with pricing to be finalized after U.S. market hours on Wednesday.

• The IPO book is covered by over five times subscription despite pricing at the low end of the range
• PayPay was offering 55 million American depositary shares with a potential valuation of up to $13.4 billion
• Market volatility from Middle East tensions is driving the conservative pricing decision

President Trump announced the opening of a new oil refinery in Brownsville, Texas, called the America First Refining project, with investment from Indian energy company Reliance. Trump characterized it as a $300 billion deal, though the scope of this figure remains unclear. The project, led by Dallas startup Element Fuels Holdings, would be the first all-new U.S. oil refinery in nearly 50 years.

• Trump claims the deal is worth $300 billion, but it is unclear whether this refers solely to the refinery or is part of a broader agreement with India
• The refinery is being developed by Element Fuels Holdings, a Dallas-area startup that is relaunching its efforts to build the facility in Brownsville
• Trump stated the project would be 'the cleanest refinery in the world' and would strengthen national security, boost energy production, and deliver billions in economic impact

Ford is launching a new AI system for its Pro commercial vehicle business to help fleet customers optimize operations and boost profits. The system, called Ford Pro AI, will monitor and analyze over 1 billion daily data points from 840,000 connected commercial vehicles. CEO Jim Farley has identified diversifying Pro's revenue through software as a crucial growth area, with software and services rapidly approaching a 20% target for Pro's earnings.

• Ford Pro AI monitors over 1 billion data points daily from connected commercial vehicles, tracking seatbelt use, vehicle health, route optimization, and fuel consumption
• The AI system will be included with Ford's existing telematics services for 840,000 paid commercial subscribers at no additional cost
• Software and physical services are 'rapidly approaching' a 20% target for Ford Pro's earnings as the company diversifies revenue beyond vehicle sales

Boeing has signed a $289 million contract with Israel to deliver up to 5,000 air-launched smart bombs, according to Bloomberg News citing three sources familiar with the deal. The agreement comes amid ongoing regional conflicts involving Israel and Iran.

• The contract is valued at $289 million for delivery of as many as 5,000 smart bombs
• Bloomberg News reported the deal based on information from three people familiar with the transaction
• The agreement occurs during active military conflict, with related Reuters reports covering the Iran war and regional tensions

Chevron and Shell are nearing major oil production deals with Venezuela following the U.S. capture of President Maduro in January, marking the first significant agreements since sanctions were imposed. The deals would allow both companies to expand operations in prime oil regions as part of what President Trump described as a $100 billion effort to rebuild Venezuela's oil industry. Venezuela reformed its oil law in late January, granting foreign companies greater autonomy to operate, export, and sell oil even as minority partners.

• Chevron is negotiating to expand its Petropiar project to the undeveloped Ayacucho 8 area in the Orinoco Belt, potentially making it the largest private producer in a region holding over three-quarters of Venezuela's crude reserves
• Shell signed preliminary agreements to develop the Carito and Pirital fields in Monagas North, an eastern region producing light and medium crude plus natural gas critical for blending with Venezuela's heavy oil
• Venezuela's total oil production currently stands at around 1.05 million barrels per day, with Chevron-PDVSA producing approximately 110,000 bpd at Petropiar and the government reviewing all oil contracts with completion expected by end of March

Oracle exceeded earnings expectations for its fiscal third quarter ended February 28, reporting revenue of $17.19 billion versus $16.91 billion expected, driven by strong cloud performance. The company's cloud revenue surged 44% year-over-year to $8.9 billion, surpassing analyst estimates. Oracle also raised its fiscal 2027 revenue guidance and now owns 15% of TikTok's U.S. business.

• Total cloud revenue reached $8.9 billion, up 44% year-over-year and exceeding the StreetAccount consensus of $8.85 billion
• Overall revenue grew 22% year-over-year to $17.19 billion with net income of $3.72 billion ($1.27 per share)
• Oracle acquired a 15% stake in TikTok's U.S. operations and lifted its fiscal 2027 revenue guidance

Dassault Aviation unveiled its Falcon 10X business jet on March 10, an $80-million long-range aircraft targeting the luxury market's top end. The French planemaker is competing with larger North American rivals by offering the market's largest cabin and range capable of connecting cities like New York and Shanghai.

• The Falcon 10X is priced at $80 million and features the largest cabin in its market segment
• The aircraft can link long-distance city pairs such as New York and Shanghai, positioning it for ultra-long-range business travel
• The rollout ceremony at Dassault's Merignac factory in France hosted suppliers and dozens of wealthy potential buyers

Amazon is expanding access to its healthcare AI assistant to all website and app users, offering help with over 30 non-emergency conditions. Previously exclusive to One Medical members, the free assistant can explain results, answer medication questions, and connect patients with providers. The move aims to reduce friction in healthcare by handling logistical and informational tasks.

• The AI assistant is free to use and does not require Prime or One Medical membership, though provider visits cost $29 for non-members
• It handles non-emergency conditions from acne to diabetes, offering symptom management, virtual assessments, and treatment advice, but does not create treatment plans
• The assistant can access medical data with permission, including lab results and clinical notes, and analyze healthcare purchases on Amazon to ask follow-up questions

Google is expanding its AI partnership with the Pentagon by launching Agent Designer, a tool enabling over 3 million Defense Department personnel to build custom AI agents for unclassified administrative tasks on GenAI.mil. This development comes one day after Anthropic sued the Trump administration for designating it a supply chain risk after refusing to allow its AI for autonomous weapons or domestic surveillance.

• The Pentagon's 3+ million staffers can use Agent Designer, a no-code/low-code tool, to create digital assistants for tasks like drafting meeting notes and breaking down projects, with expansion to classified networks under discussion
• Anthropic was recently designated a supply chain risk and removed from Pentagon systems after refusing military use of its technology for autonomous weapons or domestic surveillance, prompting the company to file a lawsuit claiming 'unprecedented and unlawful' government actions
• Google AI chief Jeff Dean and dozens of employees from Google and OpenAI signed a letter backing Anthropic's legal challenge, highlighting internal tensions over military AI applications

The International Energy Agency is convening an emergency meeting of its 30+ member countries on Tuesday to discuss releasing oil reserves in response to severe supply disruptions caused by the Iran war. The conflict has blocked tanker traffic through the Strait of Hormuz, triggering what analysts call the biggest oil supply disruption in history.

• The U.S. proposes releasing 300-400 million barrels, representing 25-30% of the IEA's 1.2 billion barrel collective reserve, though no final decision has been made
• About 20% of global petroleum consumption previously passed through the Strait of Hormuz before the war disrupted shipping, forcing Gulf Arab producers to cut output
• Saudi Aramco's CEO warned the Iran war will have 'catastrophic consequences' for global oil markets if the conflict continues